Single nucleotide substitution in the seed region of miR96 induces a significant discordance in promyleocytic leukemia zinc finger (PLZF) transcript targeting To our knowledge, the SNP (rs) in miR96 is the first confirmed example of a novel target binding site being created by a SNP within a miRNA seed sequenceOtherwise reject R (0) i (3) For each region, find all points that For the 1226 human miRNAs with SNPs in their seed region, 314 (256%) of them are located in miRNA clusters, whereas among the 1587 human miRNAs without SNPs in their seed region, only 3 (2%) of them are located in miRNA clusters (P = 606 × 10 −4, χ 2 test) (Table S2) miRNAs from the same cluster have the tendency to regulate the same sets of target genesTargetScan predicts biological targets of miRNAs by searching for the presence of 8mer, 7mer, and 6mer sites that match the seed region of each miRNA As an option, only conserved sites are predicted Also identified are sites with mismatches in the seed region that are compensated by conserved 3' pairing and centered sites In mammals, predictions are ranked based on the
New Insights Into The Function Of Mammalian Argonaute2
